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sox2 activated lung tumors  (Novogene)
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Sox2 activation accelerates lung tumor initiation and progression (A) Timeline of the Sox2 activation experiment. (B) Representative macroscopic images and corresponding computed tomography (CT) scans of non-targeted (NT) <t>and</t> <t>Sox2-activated</t> (sgSox2) PPKS lungs at 8 weeks. Scale bar, 1 cm. (C) Relative lung weights for NT and sgSox2 mice at 8 weeks ( n = 8 biological replicates/group). (D) CT voxel attenuation for NT and sgSox2 lungs at 8 weeks ( n = 11–12 biological replicates/group). (E) Histology, IHC (dCas9VP64 and Ki-67), and Alcian blue staining of NT and sgSox2 lungs at 8 weeks. Scale bars, 150 μm. (F) Quantification of dCas9VP64+ cells in NT and sgSox2 lungs at 8 weeks ( n = 8 biological replicates/group). (G) Quantification of Ki-67-positive cells in NT and sgSox2 lungs at 8 weeks ( n = 8 biological replicates/group). (H) Kaplan-Meier survival plot for NT (median survival 144 days) and sgSox2 (median survival 83 days) mice ( n = 6–7 biological replicates). Statistical significance for pairwise comparisons using Student’s two-tailed t test for bar graphs and log rank (Mantel-Cox) for survival. ∗∗ p < 0.01, ∗∗∗ p < 0.001. Error bars indicate SEM. See also .
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human lung tumor cells  (ATCC)
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Sox2 activation accelerates lung tumor initiation and progression (A) Timeline of the Sox2 activation experiment. (B) Representative macroscopic images and corresponding computed tomography (CT) scans of non-targeted (NT) <t>and</t> <t>Sox2-activated</t> (sgSox2) PPKS lungs at 8 weeks. Scale bar, 1 cm. (C) Relative lung weights for NT and sgSox2 mice at 8 weeks ( n = 8 biological replicates/group). (D) CT voxel attenuation for NT and sgSox2 lungs at 8 weeks ( n = 11–12 biological replicates/group). (E) Histology, IHC (dCas9VP64 and Ki-67), and Alcian blue staining of NT and sgSox2 lungs at 8 weeks. Scale bars, 150 μm. (F) Quantification of dCas9VP64+ cells in NT and sgSox2 lungs at 8 weeks ( n = 8 biological replicates/group). (G) Quantification of Ki-67-positive cells in NT and sgSox2 lungs at 8 weeks ( n = 8 biological replicates/group). (H) Kaplan-Meier survival plot for NT (median survival 144 days) and sgSox2 (median survival 83 days) mice ( n = 6–7 biological replicates). Statistical significance for pairwise comparisons using Student’s two-tailed t test for bar graphs and log rank (Mantel-Cox) for survival. ∗∗ p < 0.01, ∗∗∗ p < 0.001. Error bars indicate SEM. See also .
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non tumor human lung cells  (ATCC)
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Sox2 activation accelerates lung tumor initiation and progression (A) Timeline of the Sox2 activation experiment. (B) Representative macroscopic images and corresponding computed tomography (CT) scans of non-targeted (NT) <t>and</t> <t>Sox2-activated</t> (sgSox2) PPKS lungs at 8 weeks. Scale bar, 1 cm. (C) Relative lung weights for NT and sgSox2 mice at 8 weeks ( n = 8 biological replicates/group). (D) CT voxel attenuation for NT and sgSox2 lungs at 8 weeks ( n = 11–12 biological replicates/group). (E) Histology, IHC (dCas9VP64 and Ki-67), and Alcian blue staining of NT and sgSox2 lungs at 8 weeks. Scale bars, 150 μm. (F) Quantification of dCas9VP64+ cells in NT and sgSox2 lungs at 8 weeks ( n = 8 biological replicates/group). (G) Quantification of Ki-67-positive cells in NT and sgSox2 lungs at 8 weeks ( n = 8 biological replicates/group). (H) Kaplan-Meier survival plot for NT (median survival 144 days) and sgSox2 (median survival 83 days) mice ( n = 6–7 biological replicates). Statistical significance for pairwise comparisons using Student’s two-tailed t test for bar graphs and log rank (Mantel-Cox) for survival. ∗∗ p < 0.01, ∗∗∗ p < 0.001. Error bars indicate SEM. See also .
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Sox2 activation accelerates lung tumor initiation and progression (A) Timeline of the Sox2 activation experiment. (B) Representative macroscopic images and corresponding computed tomography (CT) scans of non-targeted (NT) <t>and</t> <t>Sox2-activated</t> (sgSox2) PPKS lungs at 8 weeks. Scale bar, 1 cm. (C) Relative lung weights for NT and sgSox2 mice at 8 weeks ( n = 8 biological replicates/group). (D) CT voxel attenuation for NT and sgSox2 lungs at 8 weeks ( n = 11–12 biological replicates/group). (E) Histology, IHC (dCas9VP64 and Ki-67), and Alcian blue staining of NT and sgSox2 lungs at 8 weeks. Scale bars, 150 μm. (F) Quantification of dCas9VP64+ cells in NT and sgSox2 lungs at 8 weeks ( n = 8 biological replicates/group). (G) Quantification of Ki-67-positive cells in NT and sgSox2 lungs at 8 weeks ( n = 8 biological replicates/group). (H) Kaplan-Meier survival plot for NT (median survival 144 days) and sgSox2 (median survival 83 days) mice ( n = 6–7 biological replicates). Statistical significance for pairwise comparisons using Student’s two-tailed t test for bar graphs and log rank (Mantel-Cox) for survival. ∗∗ p < 0.01, ∗∗∗ p < 0.001. Error bars indicate SEM. See also .
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Sox2 activation accelerates lung tumor initiation and progression (A) Timeline of the Sox2 activation experiment. (B) Representative macroscopic images and corresponding computed tomography (CT) scans of non-targeted (NT) <t>and</t> <t>Sox2-activated</t> (sgSox2) PPKS lungs at 8 weeks. Scale bar, 1 cm. (C) Relative lung weights for NT and sgSox2 mice at 8 weeks ( n = 8 biological replicates/group). (D) CT voxel attenuation for NT and sgSox2 lungs at 8 weeks ( n = 11–12 biological replicates/group). (E) Histology, IHC (dCas9VP64 and Ki-67), and Alcian blue staining of NT and sgSox2 lungs at 8 weeks. Scale bars, 150 μm. (F) Quantification of dCas9VP64+ cells in NT and sgSox2 lungs at 8 weeks ( n = 8 biological replicates/group). (G) Quantification of Ki-67-positive cells in NT and sgSox2 lungs at 8 weeks ( n = 8 biological replicates/group). (H) Kaplan-Meier survival plot for NT (median survival 144 days) and sgSox2 (median survival 83 days) mice ( n = 6–7 biological replicates). Statistical significance for pairwise comparisons using Student’s two-tailed t test for bar graphs and log rank (Mantel-Cox) for survival. ∗∗ p < 0.01, ∗∗∗ p < 0.001. Error bars indicate SEM. See also .
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press dendritic cell derived exosomes dex tumor antigens non small cell lung cancer phase i ii 134 exosome based vaccines  (Exosome Diagnostics)
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Sox2 activation accelerates lung tumor initiation and progression (A) Timeline of the Sox2 activation experiment. (B) Representative macroscopic images and corresponding computed tomography (CT) scans of non-targeted (NT) <t>and</t> <t>Sox2-activated</t> (sgSox2) PPKS lungs at 8 weeks. Scale bar, 1 cm. (C) Relative lung weights for NT and sgSox2 mice at 8 weeks ( n = 8 biological replicates/group). (D) CT voxel attenuation for NT and sgSox2 lungs at 8 weeks ( n = 11–12 biological replicates/group). (E) Histology, IHC (dCas9VP64 and Ki-67), and Alcian blue staining of NT and sgSox2 lungs at 8 weeks. Scale bars, 150 μm. (F) Quantification of dCas9VP64+ cells in NT and sgSox2 lungs at 8 weeks ( n = 8 biological replicates/group). (G) Quantification of Ki-67-positive cells in NT and sgSox2 lungs at 8 weeks ( n = 8 biological replicates/group). (H) Kaplan-Meier survival plot for NT (median survival 144 days) and sgSox2 (median survival 83 days) mice ( n = 6–7 biological replicates). Statistical significance for pairwise comparisons using Student’s two-tailed t test for bar graphs and log rank (Mantel-Cox) for survival. ∗∗ p < 0.01, ∗∗∗ p < 0.001. Error bars indicate SEM. See also .
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lungs cancer cell line  (ATCC)
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ATCC lungs cancer cell line
Sox2 activation accelerates lung tumor initiation and progression (A) Timeline of the Sox2 activation experiment. (B) Representative macroscopic images and corresponding computed tomography (CT) scans of non-targeted (NT) <t>and</t> <t>Sox2-activated</t> (sgSox2) PPKS lungs at 8 weeks. Scale bar, 1 cm. (C) Relative lung weights for NT and sgSox2 mice at 8 weeks ( n = 8 biological replicates/group). (D) CT voxel attenuation for NT and sgSox2 lungs at 8 weeks ( n = 11–12 biological replicates/group). (E) Histology, IHC (dCas9VP64 and Ki-67), and Alcian blue staining of NT and sgSox2 lungs at 8 weeks. Scale bars, 150 μm. (F) Quantification of dCas9VP64+ cells in NT and sgSox2 lungs at 8 weeks ( n = 8 biological replicates/group). (G) Quantification of Ki-67-positive cells in NT and sgSox2 lungs at 8 weeks ( n = 8 biological replicates/group). (H) Kaplan-Meier survival plot for NT (median survival 144 days) and sgSox2 (median survival 83 days) mice ( n = 6–7 biological replicates). Statistical significance for pairwise comparisons using Student’s two-tailed t test for bar graphs and log rank (Mantel-Cox) for survival. ∗∗ p < 0.01, ∗∗∗ p < 0.001. Error bars indicate SEM. See also .
Lungs Cancer Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Sox2 activation accelerates lung tumor initiation and progression (A) Timeline of the Sox2 activation experiment. (B) Representative macroscopic images and corresponding computed tomography (CT) scans of non-targeted (NT) and Sox2-activated (sgSox2) PPKS lungs at 8 weeks. Scale bar, 1 cm. (C) Relative lung weights for NT and sgSox2 mice at 8 weeks ( n = 8 biological replicates/group). (D) CT voxel attenuation for NT and sgSox2 lungs at 8 weeks ( n = 11–12 biological replicates/group). (E) Histology, IHC (dCas9VP64 and Ki-67), and Alcian blue staining of NT and sgSox2 lungs at 8 weeks. Scale bars, 150 μm. (F) Quantification of dCas9VP64+ cells in NT and sgSox2 lungs at 8 weeks ( n = 8 biological replicates/group). (G) Quantification of Ki-67-positive cells in NT and sgSox2 lungs at 8 weeks ( n = 8 biological replicates/group). (H) Kaplan-Meier survival plot for NT (median survival 144 days) and sgSox2 (median survival 83 days) mice ( n = 6–7 biological replicates). Statistical significance for pairwise comparisons using Student’s two-tailed t test for bar graphs and log rank (Mantel-Cox) for survival. ∗∗ p < 0.01, ∗∗∗ p < 0.001. Error bars indicate SEM. See also .

Journal: Cell Reports Medicine

Article Title: An autochthonous CRISPR activation screening platform for characterizing tissue-specific oncogene selection

doi: 10.1016/j.xcrm.2026.102759

Figure Lengend Snippet: Sox2 activation accelerates lung tumor initiation and progression (A) Timeline of the Sox2 activation experiment. (B) Representative macroscopic images and corresponding computed tomography (CT) scans of non-targeted (NT) and Sox2-activated (sgSox2) PPKS lungs at 8 weeks. Scale bar, 1 cm. (C) Relative lung weights for NT and sgSox2 mice at 8 weeks ( n = 8 biological replicates/group). (D) CT voxel attenuation for NT and sgSox2 lungs at 8 weeks ( n = 11–12 biological replicates/group). (E) Histology, IHC (dCas9VP64 and Ki-67), and Alcian blue staining of NT and sgSox2 lungs at 8 weeks. Scale bars, 150 μm. (F) Quantification of dCas9VP64+ cells in NT and sgSox2 lungs at 8 weeks ( n = 8 biological replicates/group). (G) Quantification of Ki-67-positive cells in NT and sgSox2 lungs at 8 weeks ( n = 8 biological replicates/group). (H) Kaplan-Meier survival plot for NT (median survival 144 days) and sgSox2 (median survival 83 days) mice ( n = 6–7 biological replicates). Statistical significance for pairwise comparisons using Student’s two-tailed t test for bar graphs and log rank (Mantel-Cox) for survival. ∗∗ p < 0.01, ∗∗∗ p < 0.001. Error bars indicate SEM. See also .

Article Snippet: For profiling of Sox2-activated lung tumors, stranded mRNA (polyA-selected) libraries were generated and sequenced by Novogene.

Techniques: Activation Assay, Computed Tomography, Staining, Two Tailed Test

Delineating Sox2-mediated transcriptomic reprogramming (A) Schematic of transcriptomic profiling ( n = 4 biological replicates). (B) Heatmap of all differentially expressed genes at survival endpoint (sgSox2 vs. NT). (C) Expression of Sox2 in Sox2-activated and control tumors ( n = 4 biological replicates). Error bars indicate SEM. (D) IHC of SOX2 in Sox2-activated and control lungs at 8 weeks. Scale bar, 150 μm. (E) Quantification of SOX2 IHC ( n = 4–5 biological replicates). Error bars indicate SEM. (F) Heatmap of LUSC- and LUAD-associated transcripts in Sox2-activated and control tumors. (G) Heatmap of transcripts associated with mucinous cancer and gastric metaplasia in Sox2-activated and control tumors ( n = 4 biological replicates). (H) IHC of NKX2-1, TFF1, and MUC5AC. Scale bar, 150 μm. (I) Quantification of NKX2-1, TFF1, and MUC5AC IHC at 8 weeks and survival endpoint (n = 4–5 biological replicates). EP, survival endpoint. (J) Volcano plot of mucin and gastric metaplasia genes in SOX2-high vs. -low KRAS-mutant human LUAD (TCGA-LUAD KRAS-mutant cohort, n = 89 cases). Statistical significance for pairwise comparisons using Student’s two-tailed t test for bar graphs and for multiple comparisons using one-way ANOVA with multiple comparisons correction. For differences in gene expression, adjusted p values ( q values) from DEseq2 were used. ∗ p < 0.05, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001. See also .

Journal: Cell Reports Medicine

Article Title: An autochthonous CRISPR activation screening platform for characterizing tissue-specific oncogene selection

doi: 10.1016/j.xcrm.2026.102759

Figure Lengend Snippet: Delineating Sox2-mediated transcriptomic reprogramming (A) Schematic of transcriptomic profiling ( n = 4 biological replicates). (B) Heatmap of all differentially expressed genes at survival endpoint (sgSox2 vs. NT). (C) Expression of Sox2 in Sox2-activated and control tumors ( n = 4 biological replicates). Error bars indicate SEM. (D) IHC of SOX2 in Sox2-activated and control lungs at 8 weeks. Scale bar, 150 μm. (E) Quantification of SOX2 IHC ( n = 4–5 biological replicates). Error bars indicate SEM. (F) Heatmap of LUSC- and LUAD-associated transcripts in Sox2-activated and control tumors. (G) Heatmap of transcripts associated with mucinous cancer and gastric metaplasia in Sox2-activated and control tumors ( n = 4 biological replicates). (H) IHC of NKX2-1, TFF1, and MUC5AC. Scale bar, 150 μm. (I) Quantification of NKX2-1, TFF1, and MUC5AC IHC at 8 weeks and survival endpoint (n = 4–5 biological replicates). EP, survival endpoint. (J) Volcano plot of mucin and gastric metaplasia genes in SOX2-high vs. -low KRAS-mutant human LUAD (TCGA-LUAD KRAS-mutant cohort, n = 89 cases). Statistical significance for pairwise comparisons using Student’s two-tailed t test for bar graphs and for multiple comparisons using one-way ANOVA with multiple comparisons correction. For differences in gene expression, adjusted p values ( q values) from DEseq2 were used. ∗ p < 0.05, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001. See also .

Article Snippet: For profiling of Sox2-activated lung tumors, stranded mRNA (polyA-selected) libraries were generated and sequenced by Novogene.

Techniques: Expressing, Control, Mutagenesis, Two Tailed Test, Gene Expression